CBD for mouth and teeth

How does CBD work in the oral cavity? – Overview of its anti-inflammatory properties

Cannabidiol (CBD), a non-psychoactive cannabinoid from the hemp plant, unfolds diverse mechanisms of action in the oral cavity, which are particularly important in inflammatory and painful conditions. Unlike many classic active ingredients, CBD acts not only symptomatically but also regulatory: it influences local inflammatory processes without affecting healthy tissue.

The human oral cavity has a variety of cannabinoid receptors, especially CB2 receptors, which are part of the endocannabinoid system. This system plays a central role in regulating immune responses, pain perception, and inflammatory processes. CBD exerts its effect by inhibiting pro-inflammatory cytokines and reducing the release of free radicals. This protects the mucous membranes from further irritation. CANNEFF® DENTAL GEL is a certified medical product for use on the oral mucosa. It combines anti-inflammatory, pain-relieving, and mucosa-regenerating properties without relying on antibiotics or alcohol. The key active ingredient is Cannabidiol (CBD), a non-psychoactive cannabinoid with proven anti-inflammatory effect in a patented combination with squalane.

After application, the gel forms a mucoadhesive protective layer on the mucous membrane. This barrier reduces mechanical and microbial irritants and protects the sensitive tissues from further irritation. At the same time, CBD unfolds its local anti-inflammatory effectby neutralizing oxidative stressors and inhibiting pro-inflammatory mediators. The formulation supports the regeneration of damaged mucosa, relieves pain, and reduces bleeding.

Due to its alcohol-free, non-irritating composition, the gel is particularly well tolerated – even with sensitive gums, mucosal lesions, or after surgical procedures. In modern dentistry, CANNEFF® DENTAL GEL is therefore suitable both for acute use and for prevention of recurring inflammations and mucosal diseases. Especially in diseases such as gingivitis, periodontitis, aphthae, mucositis, or after dental procedures, the local application of CBD offers a modern, non-antibiotic alternative to conventional inflammation treatment.

Can CBD help with gum inflammation (gingivitis)?

Yes, cannabidiol (CBD) can play an effective supportive role in gum inflammation, also called gingivitis, and can also act preventively. Gingivitis is a superficial inflammation of the gums caused by bacterial deposits (plaque) and tartar, which, if untreated, can progress to periodontitis. However, in the early phase, the inflammation can be well controlled, especially through targeted oral hygiene and locally effective anti-inflammatory preparations.

CBD has been proven to have anti-inflammatory, antibacterial, and antioxidant effects. It inhibits proinflammatory mediators such as TNF-α or interleukins, which play a major role in the development and maintenance of gum inflammation. At the same time, it regulates the immune response and relieves pain without irritating the mucous membranes or causing systemic side effects.

Products like CANNEFF® DENTAL GEL with CBD have been specially developed for use in the oral cavity. The gel forms a protective barrier on the inflamed gums, reduces irritation, inhibits local inflammation, and promotes mucosal regeneration – all without antibiotics or alcohol. It is therefore ideal for supportive treatment of gingivitis, especially with sensitive gums, as well as for daily oral care with an increased risk of inflammation.

What role does CBD play in the treatment of periodontitis?

CBD (Cannabidiol) is gaining increasing importance as a complementary therapeutic approach in the prevention and treatment of periodontitis. Periodontitis is a chronic inflammatory disease of the tooth-supporting apparatus that, if left untreated, leads to tooth loosening and bone loss. Unlike gingivitis, periodontitis affects not only the gums but also deeper tissue structures such as the connective tissue and the jawbone. At the center of the disease development are inflammatory processes, bacterial biofilms, and an exaggerated immune response.

CBD acts on multiple levels in this context:

• Anti-inflammatory effect: CBD inhibits the release of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6, which are partly responsible for tissue breakdown in periodontitis.
• Antibacterial effect: Studies show that CBD can inhibit the growth of periodontopathogenic bacteria.
• Oxidative stress: As a strong antioxidant, CBD neutralizes free radicals and thus protects the inflamed tissue.
• Pain reduction: The local analgesic effect of CBD can relieve pressure and pain sensation in periodontitis.

In clinical practice, CBD is ideally used in the form of a locally applied gel. CANNEFF® DENTAL GEL with CBD was specially developed for this application and supports the prevention of periodontitis. It adheres specifically to the affected mucosal areas, forms a protective barrier, and supports the regeneration of the inflamed tissue. The gel contains neither alcohol nor irritating additives or antibiotics. Clinical studies have shown great potential in the prevention and treatment of periodontitis.

Especially in the follow-up phase after a professional dental cleaning or periodontal treatment, CANNEFF CBD DENTAL GEL helps to control inflammation, prevent relapses, and stabilize the mucosal barrier. Thus, CBD, as a component of modern, certified medical products, represents a promising addition to conventional periodontitis therapy.

Does CBD gel help with peri-implant mucositis? – Support for implant patients

Yes, a CBD-containing gel like CANNEFF® DENTAL GEL can specifically support the treatment and prevention of peri-implant mucositis. Peri-implant mucositis is an inflammatory reaction of the soft tissue around a dental implant and is comparable to gingivitis on natural teeth. If not recognized and treated in time, it can progress to peri-implantitis, a deep inflammation that leads to bone loss around the implant.

CANNEFF® DENTAL GEL with CBD was specially developed for sensitive mucous membranes. It is particularly suitable for use in peri-implant complaints. In practice, it can be used as part of a comprehensive oral hygiene concept, for example after a professional cleaning, at the first signs of inflammation, or to support chronically irritated peri-implant tissues. Implant patients benefit from the targeted anti-inflammatory effect of the CBD gel as an effective and well-tolerated solution to stabilize the peri-implant soft tissue.

Lindert CBD pain and inflammation from aphthae and mucosal lesions?

Yes, CANNEFF CBD DENTAL GEL can specifically contribute to relieving pain and inflammation in aphthous ulcers and inflammatory mucosal lesions. Especially in local, non-bacterial irritations of the oral mucosa, as occur with aphthous ulcers or mechanically caused micro-injuries, CBD shows great therapeutic potential.

CANNEFF® DENTAL GEL with CBD particularly suitable for treating painful aphthous ulcers and irritative lesions in the oral cavity – e.g., caused by braces, dentures, or after dental procedures. It is free of alcohol and antibiotics, well tolerated, and can be applied directly to the affected area several times a day. CBD offers a gentle but effective alternative for the local treatment of aphthous ulcers and mucosal lesions – pain-relieving, regenerating, and anti-inflammatory. Ideal for sensitive mucous membranes and daily use as part of modern oral care.

How does CBD support wound healing after dental procedures?

CBD can effectively support wound healing after dental procedures on multiple levels. It acts anti-inflammatory, antioxidant, and locally pain-relieving, which is crucial for rapid and complication-free regeneration in the sensitive oral cavity. By inhibiting pro-inflammatory cytokines and neutralizing free radicals, the healing phase is biologically promoted while simultaneously reducing swelling, redness, and pain.

CANNEFF® DENTAL GEL specifically utilizes these properties for local application after tooth extractions, implantations, periodontal surgery, or biopsies. The gel forms a mucoadhesive protective layer on the mucous membrane, protecting the tissue from friction, germs, and irritants. This allows the wound to heal undisturbed without the need for alcohol or antibiotics. Especially for sensitive oral mucosa or at-risk patients, CANNEFF® is a modern, well-tolerated solution to support postoperative care and control pain and inflammation in everyday life.

Is CBD gel an alternative to chlorhexidine and antibiotics in oral care?

CBD acts more versatile than the active ingredient chlorhexidine – especially in mild to moderate oral inflammations. While chlorhexidine and systemic antibiotics are targeted against bacterial infections, CANNEFF CBD DNT GEL works more broadly: it has anti-inflammatory, antioxidant, pain-relieving, and tissue-regenerating properties – without typical side effects such as mucosal irritation, taste disturbances, or dysbiosis.

Unlike chlorhexidine, which can affect the oral microbiota with prolonged use, CBD supports the restoration of the natural microbial balance. The absence of alcohol also makes the gel particularly well tolerated, for example by people with sensitive mucosa or patients in oncological or periodontal aftercare.

In cases of gingivitis, peri-implant mucositis, aphthae, or after surgical procedures, a high-quality CBD gel like CANNEFF DENTAL GEL offers a gentle yet effective alternative to conventional antimicrobial products – especially when long-term or adjunctive use is required – the chlorhexidine content in CANNEFF DNT GEL is 0.04% and mainly serves as a preservative.

What advantages does CANNEFF® DENTAL GEL offer for sensitive or irritated oral mucosa?

CANNEFF® DENTAL GEL offers particularly well-tolerated, non-irritating, and at the same time medically effective support for sensitive or irritated oral mucosa. It was specially developed for use on affected mucosal areas, for example in cases of inflammation, mechanical irritation, or after dental procedures.

The advantages at a glance:

• Soothing of the mucosa through cannabidiol (CBD), which has anti-inflammatory and pain-relieving effects.
  
• Tissue regeneration through the combination with hyaluronic acid and nourishing components such as squalane.
  
• Protective function by forming a mucoadhesive film that protects against further irritations (mechanical, microbial, thermal).
  
• Alcohol-free and non-irritating – ideal for people with sensitive oral mucosa, chronic recurrent complaints, or therapy-induced mucosal damage.
  
• certified medical device – clinically tested and suitable for daily use, also as a long-term care option.
  

CANNEFF® DENTAL GEL is a gentle yet highly effective solution for relieving and preventing discomfort in the oral mucosa – particularly when conventional products are too harsh or not well tolerated.

How can CANNEFF® DENTAL GEL be integrated into daily oral hygiene?

CANNEFF® DENTAL GEL can be easily and effectively integrated into daily oral hygiene. It is especially suitable for sensitive gums, mucosal irritations, or for regeneration after dental procedures.

The recommended application is as follows:

• Brush teeth thoroughly: Use a soft toothbrush and a mild, alcohol-free toothpaste to avoid irritation.
  
• Rinse mouth: Remove toothpaste residues by gently rinsing with water or a mild rinsing solution.
  
• Apply CANNEFF® DENTAL GEL: Apply a small amount (about the size of a pea) directly to the affected area with a clean finger, cotton swab, or applicator – e.g., inflamed gums, irritated mucosa, or wound areas.
  
• Do not eat or drink immediately: For optimal adhesion and effect, food or drink should be avoided for about 20–30 minutes.

Application can be done one to three times daily – preferably after meals and before bedtime. The gel is suitable both for curative use in acute complaints and for prophylactic care in recurrent inflammations or after procedures such as tooth extractions, implantations, or periodontal treatments. Thanks to its alcohol-free, non-irritating formulation, CANNEFF® DENTAL GEL is also suitable for Long-term use suitable and thus supports stable oral mucosal health – without side effects like those of conventional antiseptic solutions or antibiotics.

What do studies say about the effectiveness of CBD for oral inflammations?

A recent study from 2024 (Jirasek et al., Journal of Periodontal Research) provides the first clinically proven evidence of the effectiveness of CBD in inflammatory diseases of the oral cavity – especially in gingivitis and early periodontitis. In the double-blind, placebo-controlled study, a total of 90 patients were treated over a period of 56 days. It was shown that the regular use of a CBD-containing gel led to a significant improvement in key inflammatory parameters such as the gingival index (GI), the modified gingival index (MGI), and the bleeding tendency of the gums (GBI). At the same time, unlike conventional antiseptic agents such as chlorhexidine, no undesirable side effects occurred. Another clinical study with CANNEFF DENTAL GEL on peri-implant mucositis was successfully completed. 

Promising effects have also been demonstrated preclinically: In cell models, cannabidiol reduced the release of pro-inflammatory cytokines (such as IL-6 and IL-8), inhibited the growth of periodontitis pathogens such as Porphyromonas gingivalis and activated the cell-protective Nrf2 signaling cascade. These results confirm that CBD is not only anti-inflammatory but also antimicrobial and antioxidant – a promising approach for the local treatment of oral inflammations. Products like CANNEFF® DENTAL GEL, which contain CBD in medically effective concentrations, thus offer a modern, well-tolerated alternative to conventional preparations.