CBD for menstrual discomfort

How does CBD affect menstrual pain?

CBD can act on menstrual pain through multiple mechanisms described in various studies. Central to this is especially its possible influence on inflammatory processes and pain perception: Some studies indicate that CBD inhibits enzymes and signaling molecules that enhance pain perception, for example by reducing prostaglandin synthesis. Prostaglandins are involved in the development of cramps and pain during menstruation. Furthermore, research suggests that CBD could modulate certain receptors and channels (e.g., TRPV1), which can additionally have pain-relieving effects. In studies on dysmenorrhea, a corresponding decrease in pain intensity and a reduced need for conventional painkillers were observed when CBD was used.

Reduction of inflammatory mediators (prostaglandins, cytokines)
Several studies suggest that cannabidiol (CBD), similar to common painkillers (e.g., nonsteroidal anti-inflammatory drugs), can interfere with prostaglandin metabolism by blocking enzymes involved in the formation of pain-causing prostaglandins. Prostaglandins, in turn, play a central role in menstrual cramps and pain as they promote contraction of the uterine muscles. Additionally, research shows that CBD could regulate or reduce inflammatory markers such as IL-1β, IL-6, or TNF-α, which can further alleviate inflammatory pain.

Modulation of the Endocannabinoid System (ECS)
The endocannabinoid system plays an important role in the female reproductive cycle. CBD interacts with this system in various ways, including by influencing receptors (e.g., CB1, CB2) and ion channels (e.g., TRPV1). In this way, pain signals in the periphery and central nervous system can be alleviated. Studies that have used CBD for dysmenorrhea-related pain report both subjective and objectively measured pain relief, which is often accompanied by changes in ECS regulation.

Reduction of cramps and muscle contractions
Since prostaglandins stimulate the uterus to stronger contractions, their reduction by CBD can lead to a decrease in the intensity of uterine cramps. Analogous to conventional painkillers (such as ibuprofen), initial comparative studies indicate that CBD can alleviate both the frequency and strength of such cramps.

Support against accompanying symptoms
In addition to direct pain modulation, several studies describe that CBD could have a calming or anxiolytic effect. Since menstrual complaints often go hand in hand with inner restlessness, tension, or sleep problems, this effect can further reduce the overall perception of pain.

Possible rapid effect through specific forms of administration
Various forms of administration, for example vaginal suppositories, showed in initial studies sometimes faster relief than oral variants. However, individual differences (e.g., dosage, type of application) are large here.

Overall, the available studies suggest that CBD may be involved in relieving menstrual pain both through anti-inflammatory effects and direct influence on the endocannabinoid system. However, the research situation recommends further, preferably placebo-controlled long-term studies to precisely determine optimal dosages and methods of administration.

Can CBD relieve cramps during the period?

Menstrual complaints are often due to complex processes in the body. The so-called prostaglandins play a special role here – hormone-like substances that are increasingly produced in the uterus and can trigger strong contractions. CBD (cannabidiol) is attributed with the ability to reduce the production of these pain-enhancing messenger substances by inhibiting certain enzymes responsible for the formation of prostaglandins. As a result, the frequency and strength of uterine cramps are reduced, leading to noticeable relief in the lower abdomen.

Another aspect is the possible anti-inflammatory effect of CBD. During menstruation, inflammatory processes can occur that additionally increase the perception of pain. By influencing the release of proinflammatory substances, CBD could help to alleviate inflammatory reactions in the lower abdomen and thus reduce the intensity of cramps.

Furthermore, the endocannabinoid system (ECS) is of importance. This regulatory system has a significant influence on pain processing and body homeostasis. Cannabidiol can ensure that pain stimuli are dampened via certain receptors and ion channels (including the TRPV1 receptor channel). Studies that have specifically examined CBD for menstrual pain often report a decrease in cramp and pain intensity, sometimes also a reduced need for conventional painkillers like ibuprofen.

Some users also prefer local forms of application such as vaginal suppositories, as they suspect a faster effect. Others rely on oil or capsules absorbed through the gastrointestinal tract. Ultimately, the choice of dosage form is individual and depends on personal preferences and tolerances.

Although numerous case reports and initial study results suggest a significant relief of menstrual cramps, the data is not yet conclusive. Larger, placebo-controlled studies are needed to scientifically determine precise dosage recommendations, duration of effect, and possible long-term effects. Nevertheless, current findings indicate that CBD may be a promising option to reduce the intensity of period cramps.

What effect does CBD have on hormone balance?

Although the endocannabinoid system is involved in various hormonal processes, previous studies have not demonstrated a clear influence of cannabidiol (CBD) on the female hormonal balance. For example, there is no conclusive evidence that CBD directly alters estrogen or progesterone levels. Most research focuses instead on the anti-inflammatory and pain-relieving properties of CBD, such as in menstrual pain or endometriosis. It is conceivable that the modulatory effect of CBD on the endocannabinoid system indirectly influences hormonal processes. However, there are no definitive studies specifically addressing this aspect. Therefore, it cannot yet be conclusively stated whether and to what extent CBD has a long-term impact on the female hormonal balance.

Are there studies on CBD for menstrual pain?

Yes, there are several scientific studies that deal with how cannabidiol (CBD) affects menstrual pain and associated symptoms. Below is an overview in table form, with the respective authors and publication year listed in the first column:

These studies indicate that CBD could be an effective option for menstrual complaints, especially primary dysmenorrhea. Several reports mention a noticeable reduction in pain as well as a decrease in accompanying symptoms such as irritability and sleep problems. However, most publications point to the need for larger, methodologically stricter studies to better understand the optimal dosage, possible long-term effects, and the exact efficacy profile.

What forms of CBD are recommended for menstrual pain?

Based on the currently available studies, two application forms are particularly noteworthy for relieving menstrual complaints:

• Oral products (Oils, capsules) usually offer a slow onset but relatively long-lasting effect.

• Vaginal suppositories According to Dahlgren et al. (2024), they can help quickly and effectively because the CBD is absorbed directly through the mucous membrane.

Larger, methodologically sound studies are still lacking to determine, among other things, exact dosages and potential long-term effects of the respective application forms. Nevertheless, the studies available so far provide indications that both oral and vaginal CBD products can be a supportive measure for menstrual pain.

When should one take CBD during the cycle?

The intake times and intervals for cannabidiol (CBD) considered in the available studies vary, with two basic approaches identifiable:

Intake from the onset of first pain (e.g., from day 1 of menstruation):
In a phase II study with patients suffering from primary dysmenorrhea, CBD was used on the first days of menstruation – often for three consecutive days. Mohan et al. (2022). Over several cycles, subjects took CBD for five consecutive days, starting on the day the first symptoms (e.g., cramps) appeared. Ferretti et al. 2024.

As needed: Participants could use high-dose CBD suppositories "as needed" (pro re nata, PRN) for menstrual complaints, often already in the premenstrual period or at the latest at the start of bleeding. Dahlgren et al. 2024.

Studies show that many users begin taking it at the onset of the first pain or discomfort (often day 1 of menstruation) and continue for several days. Some studies also recommend preventive use in the premenstrual period, especially if cramps and pain regularly occur. However, there is still no universal standard, so the optimal intake phase can vary individually. Depending on personal tolerance and pain progression, starting CBD use shortly before or directly at the beginning of menstruation may be advisable.

Is CBD helpful for PMS (premenstrual syndrome)?

The use of CBD in the form of vaginal suppositories can provide effective support for PMS symptoms. Modern products like the CANNEFF vaginal suppositories combine cannabidiol (CBD) and hyaluronic acid in a patented emulsion matrix to achieve the following effects:

Anti-inflammatory and antioxidant effects
CBD has both anti-inflammatory and antioxidant properties that can reduce pain and irritation in the vaginal area. This is particularly helpful for complaints such as lower abdominal pain or itching, which frequently occur during PMS.

Moisturizing and mucous membrane regeneration
Due to the addition of hyaluronic acid, the suppositories have a moisturizing effect and support the regeneration of irritated mucous membranes. In this way, vaginal dryness, which occurs in many women during the PMS phase, can be alleviated.

Natural, non-hormonal option
Originally developed for women in menopause, CANNEFF suppositories have also been shown to be effective for PMS according to available information. Since they are hormone-free, they represent a natural alternative to conventional PMS treatments. Women who wish to avoid hormonal therapies especially benefit from this approach.

Improved overall well-being
Users report relief from both physical complaints (e.g., pain, itching) and accompanying symptoms such as sleep disturbances or restlessness. Improved sleep quality and reduced stress can enhance overall well-being during the premenstrual phase.

CBD vaginal suppositories like those from CANNEFF can alleviate PMS symptoms through anti-inflammatory and moisturizing properties, offering a natural, non-hormonal alternative for preventing or reducing premenstrual complaints. It is advisable to follow the manufacturer's instructions and, if necessary, seek medical advice to receive individually suitable application recommendations.

Can CBD help with pain caused by endometriosis?

Yes, various studies suggest that CBD can be a promising option for relieving endometriosis-related pain. Endometriosis is a chronic inflammatory disease in which uterine lining-like tissue grows outside the uterus and often causes severe pain. CBD acts at several points that are also significant for endometriosis:

Inhibition of inflammation and angiogenesis
In specialist articles about endometriosis, it is described that CBD can reduce inflammatory factors such as IL-1β, IL-6, or TNF-α. These messengers promote the growth and spread of endometriosis lesions. By lowering inflammation and potentially inhibiting the formation of new blood vessels (angiogenesis), CBD may reduce the supply to the overactive tissue and thereby potentially slow its growth.

Pain-relieving effect
In endometriosis, high prostaglandin levels and neuroinflammatory mechanisms often play a role, causing severe pain. According to some studies, CBD can reduce the production of these pro-inflammatory messengers and additionally modulate certain receptors (e.g., TRPV1), which could dampen pain perception. In initial observational uses, affected individuals report a noticeable reduction in pain intensity – sometimes comparable to conventional painkillers.

Perspectives for further research
Although the previous results are positive, many studies are still small or lack a placebo comparison. Experts therefore emphasize that larger, controlled studies are needed to conclusively assess the efficacy and safety of CBD in endometriosis. The optimal dosage, form of administration (e.g., oral vs. vaginal), and duration of use have also not yet been clearly established.

How quickly does CBD work for menstrual pain?

Existing studies show partly different information regarding the onset of action of cannabidiol (CBD). Two factors play a role here: the chosen form of administration (e.g., oral vs. vaginal) and individual differences such as metabolism, body weight, or pain sensitivity.

Oral intake (e.g., oil, capsules): The subjects studied used CBD in tablet form against dysmenorrhea. Pain levels were recorded at specific time intervals (e.g., after 1, 2, 3 hours). The data suggest that pain relief usually begins within the first one to two hours after intake but can remain stable over several hours, according to Mohan. et al. 2022Participants took orally administered CBD over several cycles. Although the overall effect was mostly measured over days, some affected individuals report noticeable relief already within one to two hours after intake. Ferretti et al. 2024.

Vaginal suppositories: In this quasi-experimental study on high-dose (100 mg) CBD suppositories, many users were asked when they noticed an improvement in their menstrual complaints. It states that a noticeable effect often occurs "quickly," sometimes within an hour. Due to direct absorption through the vaginal mucosa, CBD can reach the surrounding tissues faster, which can promote quicker pain relief, according to Dahlgren. et al. 2024.

Oral products generally take effect within about one to two hours, whereas vaginal suppositories, according to some experience and study reports, can sometimes work in under an hour. However, since there are large individual differences, users should try which form and timing of administration best suit their personal symptom profile.

Studies with CANNEFF vaginal suppositories containing 100 mg for menopausal complaints showed, in addition to effects on vaginal dryness and pain, a significant reduction of physiological symptoms of menopause, e.g., hot flashes, sleep disturbances, mood swings, joint problems. The suppositories were used daily for 30 days in the placebo-controlled study. An improvement in quality of life was also achieved.

What do users say about CBD during their period?

Users of high-dose vaginal suppositories (100 mg CBD) often described a "significant" reduction in their menstrual pain. A large proportion reported that the symptoms subsided faster compared to conventional pain medication use. Although there are differences between individual forms of administration and dosages, many users overall describe relief from menstrual pain and sometimes a reduction of other troublesome symptoms (e.g., sleep disturbances, irritability). Women who used CBD regularly over several consecutive cycles mentioned, in addition to relief from lower abdominal cramps, a decrease in stress, irritability, or sleep problems. In a direct comparison with ibuprofen, users mostly expressed positive views regarding tolerability and found CBD to be a "pleasant" alternative without significant side effects (e.g., less nausea or stomach issues). Women who used vaginal suppositories reported in surveys (e.g., Dahlgren et al., 2024) sometimes a faster onset of effect than with oral preparations. Despite this positive feedback, larger placebo-controlled studies such as those with CANNEFF vaginal suppositories for menopausal complaints are needed to verify such reports and to make concrete recommendations for menstrual complaints.